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Semaglutide

Also known as Ozempic, Wegovy, Rybelsus

A GLP-1 receptor agonist that increases glucose-dependent insulin release, reduces glucagon signaling, slows gastric emptying, and influences appetite pathways.

Tirzepatide

Also known as Mounjaro, Zepbound

A dual GIP and GLP-1 receptor agonist that alters glucose-dependent insulin and glucagon signaling while engaging appetite-regulation pathways.

Retatrutide

Also known as LY3437943, Reta

An investigational triple agonist designed to activate GIP, GLP-1, and glucagon receptors; its combined metabolic effects remain under clinical study.

Cagrilintide

Also known as AM833, Cagri

A long-acting amylin analogue being studied for signaling through amylin and calcitonin-family receptors involved in satiety and gastric emptying.

Bremelanotide

Also known as PT-141, Vyleesi

A melanocortin receptor agonist thought to act mainly through central MC4 receptors involved in sexual-response signaling; its precise therapeutic pathway is not fully known.

Oxytocin

Also known as Pitocin

An endogenous hormone that activates oxytocin receptors, triggering calcium-dependent smooth-muscle contraction and signaling in reproductive and social-behavior circuits.

GHK-Cu

Also known as Copper tripeptide-1, Copper peptide

A copper-binding tripeptide studied for regulating extracellular-matrix, wound-response, and antioxidant-related gene activity; topical and systemic claims are not interchangeable.

Melanotan II

Also known as MT-II, MT-2

A synthetic melanocortin agonist that can activate several melanocortin receptors, including pigment-related MC1 and appetite or sexual-response pathways involving MC3 and MC4.

Epitalon

Also known as Epithalon

A synthetic tetrapeptide studied mainly in cell and animal models; proposed effects on telomerase and pineal or circadian signaling are not established human mechanisms.

MOTS-c

Also known as MOTS-C

A mitochondria-derived peptide that can inhibit folate-linked purine synthesis, increase AICAR, activate AMPK, and participate in cellular stress-response signaling.

Tesamorelin

Also known as Egrifta SV, Egrifta WR

A growth-hormone-releasing hormone receptor agonist that stimulates pulsatile pituitary growth-hormone release and downstream IGF-1 production.

Sermorelin

Also known as Sermorelin acetate, Geref

An analogue of growth-hormone-releasing hormone that activates pituitary GHRH receptors to stimulate endogenous, pulsatile growth-hormone secretion.

CJC-1295

Also known as CJC-1295 with DAC, DAC:GRF

A long-acting GHRH analogue designed to activate pituitary GHRH receptors and prolong growth-hormone and IGF-1 signaling; human evidence is limited.

Ipamorelin

Also known as Ipamorelin acetate

A growth-hormone secretagogue that activates the ghrelin receptor and can stimulate pituitary growth-hormone release; it remains investigational.

BPC-157

Also known as Body Protection Compound-157

A synthetic gastric-pentadecapeptide fragment with proposed effects on nitric-oxide, angiogenic, and tissue-repair pathways in preclinical models; no confirmed human mechanism exists.

TB-500

Also known as Thymosin beta-4 fragment LKKTETQ

A short thymosin-beta-4-related fragment marketed for repair; fragment-specific biological activity and a human mechanism have not been established.

Thymosin alpha-1

Also known as Ta1, Thymalfasin

An immune-active thymic peptide studied for modulating dendritic-cell, T-cell, and innate immune signaling rather than acting through one established receptor.

Semax

Also known as Semax heptapeptide

An ACTH(4-10)-derived peptide whose preclinical neurotropic effects are associated with increased BDNF and TrkB signaling; its direct molecular target remains uncertain.

Selank

Also known as Selank acetate, TP-7

A tuftsin-derived peptide studied for anxiety and stress effects through proposed subtype-selective positive allosteric modulation of GABA receptors.

AOD-9604

Also known as AOD9604, hGH fragment 177-191

A modified growth-hormone fragment developed to reproduce proposed fat-metabolism signaling without full growth-hormone activity; a validated human molecular target is lacking.

Acetyl Dipeptide-1 Cetyl Ester

Also known as Calmosensine

A lipid-modified cosmetic dipeptide marketed for skin-comfort signaling, with proposed modulation of sensory-neuron pathways rather than a clinically established mechanism.

Acetyl Hexapeptide-30

A cosmetic peptide proposed to reduce expression-related skin movement by influencing neuromuscular signaling; independent mechanistic evidence is sparse.

Acetyl Hexapeptide-8

Also known as Argireline

A SNAP-25-mimicking cosmetic peptide proposed to interfere with SNARE-complex assembly and neurotransmitter release, although topical penetration and in-skin activity remain uncertain.

Acetyl Octapeptide-3

Also known as SNAP-8

A longer SNAP-25-inspired cosmetic peptide proposed to compete in SNARE-complex formation and reduce neurotransmitter release associated with expression lines.

Acetyl sh-Heptapeptide-1

A recombinant cosmetic peptide marketed as a skin-conditioning signal; its specific receptor, pathway, and human mechanism are not well established.

Acetyl Tetrapeptide-5

Also known as Eyeseryl

A cosmetic tetrapeptide proposed to influence fluid balance, glycation, and extracellular-matrix pathways around the eye; evidence is primarily ingredient-level.

AHK-Cu

Also known as Copper tripeptide AHK-Cu

A copper-binding tripeptide studied for signaling related to hair-follicle activity and extracellular-matrix remodeling; clinical mechanism evidence remains limited.

Biotinoyl Tripeptide-1

A biotin-linked cosmetic peptide marketed to support hair anchoring and extracellular-matrix proteins around follicles; a confirmed human target has not been established.

Bronchogen

A short peptide bioregulator marketed for respiratory tissue support; a reproducible molecular target and validated human mechanism have not been established.

Calcitonin Salmon

Also known as Salmon calcitonin

A calcitonin-receptor agonist that suppresses osteoclast-mediated bone resorption and can alter renal handling of calcium and phosphate.

Cardiogen

A peptide bioregulator marketed for cardiovascular tissue effects, but reliable literature does not establish a specific receptor or human mechanism.

Cartalax

A short peptide bioregulator marketed for cartilage-related effects; its molecular target and mechanism in humans remain unverified.

CB4211

An investigational analogue of MOTS-c designed to influence AMPK-linked metabolic and liver pathways; its exact human mechanism remains under study.

Cibinetide

Also known as ARA-290

A non-erythropoietic erythropoietin-derived peptide proposed to activate an innate-repair receptor complex involving EPOR and CD131.

Cyclosporine

Also known as Ciclosporin

A calcineurin inhibitor that complexes with cyclophilin, suppressing NFAT activation and reducing transcription of IL-2 and other T-cell cytokines.

Dihexa

An experimental angiotensin-IV-derived compound proposed to potentiate hepatocyte growth factor signaling at the c-Met receptor; evidence is preclinical.

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Also known as Syn-Ake

A venom-inspired cosmetic dipeptide proposed to antagonize nicotinic acetylcholine receptors and reduce muscle-contraction signaling near expression lines.

DSIP

Also known as Delta sleep-inducing peptide

A naturally described peptide associated with sleep research, but its receptor, physiological role, and administered-drug mechanism remain unresolved.

Dulaglutide

Also known as Trulicity

A long-acting GLP-1 receptor agonist that increases glucose-dependent insulin secretion, reduces glucagon release, and slows gastric emptying.

EGF

Also known as Epidermal growth factor

A growth factor that binds EGFR, activates receptor tyrosine-kinase signaling, and regulates epithelial-cell proliferation, migration, and differentiation.

Elamipretide

Also known as SS-31, MTP-131

A mitochondria-targeting peptide that associates with cardiolipin in the inner mitochondrial membrane and modulates membrane structure, protein organization, and bioenergetics.

Exenatide

Also known as Byetta, Bydureon

A GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon, and slows gastric emptying.

FOXO4-DRI

A cell-penetrating experimental peptide designed to disrupt FOXO4-p53 binding and promote apoptosis in senescent cells; evidence is preclinical.

GHK

Also known as Glycyl-L-histidyl-L-lysine

An endogenous copper-binding tripeptide studied as a signaling and carrier molecule in tissue remodeling, extracellular-matrix regulation, and wound response.

GHRP-2

Also known as Pralmorelin

A ghrelin-receptor agonist and growth-hormone secretagogue that stimulates pituitary growth-hormone release and can also affect appetite signaling.

GHRP-6

A synthetic ghrelin-receptor agonist that stimulates growth-hormone release and strongly engages appetite-related signaling; it is not an approved therapy.

Glucagon

A glucagon-receptor agonist that activates hepatic cAMP signaling, increasing glycogen breakdown and glucose production while relaxing gastrointestinal smooth muscle.

Glutathione

Also known as GSH

An intracellular tripeptide that participates directly in redox buffering and serves as a substrate for glutathione-dependent detoxification enzymes.

Gonadorelin

Also known as GnRH

A synthetic GnRH that activates pituitary GnRH receptors, producing time-pattern-dependent release of luteinizing hormone and follicle-stimulating hormone.

Hexapeptide-10

Also known as Serilesine

A laminin-derived cosmetic peptide proposed to support keratinocyte adhesion and basement-membrane or extracellular-matrix organization.

Hexapeptide-11

A yeast-derived cosmetic hexapeptide studied for skin-conditioning and cell-signaling effects, but its direct target is not established.

Hexarelin

A synthetic ghrelin-receptor agonist that stimulates pituitary growth-hormone release and has additional proposed cardiovascular signaling effects.

hGH Fragment 176-191

Also known as HGH Frag 176-191

A C-terminal growth-hormone fragment marketed for fat-metabolism effects; its independent receptor and clinically validated human mechanism are not established.

Human Chorionic Gonadotropin

Also known as hCG, Chorionic gonadotropin

A luteinizing-hormone receptor agonist that stimulates gonadal steroid production and supports ovulation or testicular testosterone signaling, depending on context.

Humanin

A mitochondria-derived peptide with proposed cytoprotective signaling through receptors including FPRL1 and CNTFR-containing complexes, plus intracellular anti-apoptotic interactions.

IGF-1

Also known as Insulin-like growth factor 1

A growth factor that activates the IGF-1 receptor tyrosine kinase, engaging PI3K-AKT and MAPK pathways involved in growth, survival, and metabolism.

IGF-1 DES

Also known as DES(1-3) IGF-1

A shortened IGF-1 analogue with reduced binding to IGF-binding proteins and retained IGF-1 receptor activity; evidence is predominantly laboratory-based.

IGF-1 LR3

A modified IGF-1 analogue engineered for lower binding-protein affinity and prolonged IGF-1 receptor signaling; it is not an approved human drug.

Immune Peptide A2

A seller-named peptide identity for which a reproducible sequence, receptor, and independently supported mechanism could not be established.

Kisspeptin

An endogenous ligand for KISS1R that stimulates hypothalamic GnRH release and thereby activates downstream LH and FSH reproductive signaling.

Kisspeptin-10

The active C-terminal kisspeptin fragment that activates KISS1R and stimulates the hypothalamic-pituitary-gonadal axis through GnRH release.

KPV

Also known as Lys-Pro-Val

The Lys-Pro-Val fragment of alpha-MSH, studied preclinically for anti-inflammatory effects involving NF-kappa-B and cytokine signaling; no established human target is confirmed.

Larazotide

Also known as Larazotide acetate, AT-1001

A tight-junction regulator proposed to inhibit zonulin-associated increases in intestinal permeability; its precise molecular interaction remains incompletely defined.

Linaclotide

Also known as Linzess

A guanylate cyclase-C agonist that raises intestinal cyclic GMP, increasing chloride and bicarbonate secretion and modulating visceral pain signaling.

Liraglutide

Also known as Saxenda, Victoza

A long-acting GLP-1 receptor agonist that increases glucose-dependent insulin release, lowers glucagon secretion, slows gastric emptying, and influences appetite.

LL-37

Also known as Cathelicidin LL-37

An endogenous cathelicidin with membrane-disrupting antimicrobial activity and broad immune-signaling effects; those actions vary greatly by concentration and environment.

Mazdutide

Also known as IBI362, LY3305677

An investigational dual GLP-1 and glucagon receptor agonist designed to combine appetite and glucose signaling with glucagon-linked energy-expenditure effects.

Melanotan I

Also known as Afamelanotide analogue, MT-1

An alpha-MSH analogue that activates melanocortin receptors, particularly pigment-related MC1 receptors; marketed MT-1 products are not equivalent to approved afamelanotide.

Menotropins

Also known as Human menopausal gonadotropin, hMG

A mixture of FSH and LH activity that stimulates ovarian follicular development or testicular spermatogenesis and steroidogenesis through gonadotropin receptors.

Myristoyl Pentapeptide-16

A lipid-modified cosmetic peptide marketed to influence keratin production and lash or hair appearance; independent human mechanistic evidence is limited.

Myristoyl Tripeptide-31

A lipid-modified cosmetic tripeptide marketed for skin-renewal signaling; a specific validated receptor or human mechanism has not been established.

N-Acetyl Selank

An acetylated Selank analogue intended to alter peptide stability; GABA-related activity is inferred from Selank rather than independently established in humans.

N-Acetyl Selank Amidate

A terminally modified Selank analogue marketed for greater stability; its receptor pharmacology and human mechanism have not been independently characterized.

N-Acetyl Semax

An acetylated Semax analogue intended to resist degradation; proposed BDNF-related activity is extrapolated from Semax and lacks independent human confirmation.

N-Acetyl Semax Amidate

A terminally modified Semax analogue marketed for stability; its direct target and human mechanism have not been independently established.

OS-01 Peptide

A proprietary cosmetic peptide designed to reduce senescence-associated signaling in skin cells; public evidence does not establish a single molecular target.

Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine

A lipid-modified cosmetic peptide marketed to support laminin and basement-membrane signaling; evidence is largely ingredient and formulation based.

Palmitoyl Hexapeptide-19

A lipid-modified cosmetic peptide proposed to influence neuromuscular signaling and the appearance of expression lines; its in-skin target remains uncertain.

Palmitoyl Pentapeptide-4

Also known as Matrixyl

A matrikine-inspired cosmetic peptide proposed to signal fibroblasts to increase extracellular-matrix proteins such as collagen; topical efficacy varies by formulation.

Palmitoyl Tetrapeptide-7

A lipid-modified cosmetic peptide proposed to modulate inflammatory signaling and extracellular-matrix breakdown, often used in multi-peptide formulations.

Palmitoyl Tripeptide-1

A lipid-linked collagen-derived matrikine proposed to signal fibroblasts and support extracellular-matrix synthesis in cosmetic formulations.

Palmitoyl Tripeptide-5

Also known as Syn-Coll

A cosmetic peptide proposed to influence TGF-beta-related collagen signaling; direct human skin evidence and penetration remain limited.

PE-22-28

An experimental peptide derived from the antidepressant spadin and proposed to inhibit TREK-1 potassium channels; evidence is preclinical.

PEG-MGF

Also known as PEGylated mechano growth factor

A PEGylated analogue of an IGF-1 splice-product fragment intended to prolong exposure; receptor activity and human effects are not clinically established.

Pentadeca Arginate

A highly cationic arginine-rich peptide marketed in cosmetic products, but its sequence-specific biological target and human mechanism are not established.

Pentapeptide-18

Also known as Leuphasyl

An enkephalin-inspired cosmetic peptide proposed to reduce acetylcholine release by engaging enkephalin receptors near neuromuscular junctions.

Pinealon

A synthetic tripeptide bioregulator studied for neuroprotective and gene-expression effects, but no validated receptor or human mechanism is established.

PNC-27

An experimental p53-derived peptide designed to bind HDM2 or MDM2 on cancer-cell membranes and form membrane-disrupting pores; evidence is preclinical.

PTD-DBM

An experimental cell-penetrating peptide designed to block CXXC5 binding to Dishevelled and thereby enhance Wnt or beta-catenin signaling.

Setmelanotide

Also known as Imcivree

A selective MC4 receptor agonist that restores melanocortin satiety signaling in certain genetically defined obesity pathways.

sh-Oligopeptide-10

A recombinant cosmetic peptide marketed for antimicrobial or skin-conditioning activity; sequence-specific human mechanism evidence is limited.

sh-Oligopeptide-2

A recombinant IGF-1-like cosmetic ingredient intended to engage growth-factor signaling, although topical delivery and equivalence to native IGF-1 are not established.

sh-Polypeptide-1

Also known as Recombinant human EGF

A recombinant EGF cosmetic ingredient intended to activate EGFR-related epithelial renewal signaling; topical penetration and product-level activity vary.

sh-Polypeptide-11

A recombinant growth-factor-style cosmetic ingredient marketed for skin conditioning; public nomenclature does not establish one consistent molecular identity or target.

sh-Polypeptide-9

A recombinant cosmetic polypeptide marketed for growth-factor-like skin signaling; its exact identity and human mechanism depend on the formulation.

Somatropin

Also known as Recombinant human growth hormone, rhGH

Recombinant human growth hormone that activates the growth-hormone receptor, JAK2-STAT signaling, and hepatic or tissue IGF-1 production.

Survodutide

Also known as BI 456906

An investigational dual glucagon and GLP-1 receptor agonist designed to combine appetite regulation with glucagon-linked metabolic signaling.

Thymalin

A thymic peptide extract or mixture marketed for immune regulation; variable composition prevents assignment of one precise molecular mechanism.

Thymogen

The dipeptide glutamyl-tryptophan, studied as an immune-modulating bioregulator; a specific receptor-mediated human mechanism has not been established.

Thymosin Beta-4

Also known as Tbeta4, Tβ4

An endogenous actin-binding peptide that sequesters G-actin and participates in cell migration, angiogenesis, inflammation, and tissue-repair signaling.

Thymulin

A zinc-dependent thymic nonapeptide that can modulate T-cell and neuroendocrine signaling; its effects depend on zinc binding and biological context.

Vasoactive Intestinal Peptide

Also known as VIP, Aviptadil

An endogenous neuropeptide that activates VPAC1 and VPAC2 receptors, increasing cyclic AMP and affecting smooth muscle, secretion, and immune signaling.

Vesugen

A short peptide bioregulator marketed for vascular tissue support, but a reproducible molecular target and validated human mechanism are not established.

Zinc Thymulin

The zinc-bound active form of thymulin, associated with thymic immune and neuroendocrine signaling rather than a single well-defined receptor pathway.

NAD+

Also known as Nicotinamide adenine dinucleotide, NAD, NADH (reduced form)

A cellular redox cofactor and substrate for enzymes including sirtuins, PARPs, and CD38; it is peptide-adjacent rather than a peptide receptor agonist.

Orforglipron

Also known as Foundayo

An investigational nonpeptide GLP-1 receptor agonist that activates GLP-1 signaling orally; it is tracked as peptide-adjacent.

Nicotinamide Mononucleotide

Also known as NMN

A nucleotide precursor that can feed cellular NAD+ biosynthesis through nicotinamide mononucleotide adenylyltransferases; human tissue uptake pathways remain debated.